B and T cell epitopes of glycoprotein D of herpes simplex virus type 1

Immunogenicity and Efficacy of Baculovirus Derived Glycoprotein D of Herpes Simplex Virus Type-I in Mice

Localization of epitopes of herpes simplex virus type 1 glycoprotein D.

We previously defined eight groups of monoclonal antibodies which react with distinct epitopes of herpes simplex virus glycoprotein D (gD). One of these, group VII antibody, was shown to react with a type-common continuous epitope within residues 11 to 19 of the mature glycoprotein (residues 36 to 44 of the predicted sequence of gD). In the current investigation, we have localized the sites of ...

Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B.

The identification of "asymptomatic" (i.e., protective) epitopes recognized by T cells from herpes simplex virus (HSV)-seropositive healthy individuals is a prerequisite for an effective vaccine. Using the PepScan epitope mapping strategy, a library of 179 potential peptide epitopes (15-mers overlapping by 10 amino acids) was identified from HSV type 1 (HSV-1) glycoprotein B (gB), an antigen th...

Application of McCoy Cell Line for Propagation of Herpes Simplex Virus Type 1

Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) are members of the Herpesviridae family. About 40% to 80% of the world populations are infected with HSV and its prevalence is high in Iran. The high prevalence of this virus in the community and the ability of the virus in causing fatal diseases among immunocompromised patients, have encouraged studies to be performed on HSV and suitable cell ...

The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture

Background: Cumin (Cuminum cyminum L. [family Apiaceae]) seed essential oil is reported to have antiseptic activity. Until now the antiviral properties of cumin seed extracts on viruses such as herpes simplex virus-1 (HSV-1) have not been studied. The objective of this study was to investigate the in vitro effects of aqueous, methanolic and hydroalcoholic extracts of cumin seed on HSV-1 growth ...